Lo Key began his career in metal bands in the late 1990s, but eventually decided to pursue hip hop. In the early 2000s, Lo Key founded the group Temple Rain featuring members Green Vilin and Sleepy. The group released two albums before disbanding in 2004.
In the mid-2000s, he would go on to release several solo albums including Follow Me, The House 1, The House 2, SO-LO, Jack Yo Beatz 1 and Jack Yo Beatz 2. In 2006, Lo Key created the group MISSION : INFECT featuring numerous underground artists including Menacide, Q-Strange, Saint Sinna, BadLuck, Grewsum, T.O.N.E-Z, Malaria, Tha Wikid One, Madd Maxxx, Green Vilin, and more. As a group, they released the projects Chemical Threats 1 & 2, xterM:Ination, and Asphyxiation. Several unofficial mixtapes were also produced.
Lo Key and MISSION : INFECT also performed 4 consecutive years at the Gathering of the Juggalos. Lo Key was also featured on Psychopathic Records 2008 compilation album Tunnel Runners, which debuted at #21 on Billboards Top Rap Albums.
After a short hiatus in 2010, Lo Key would go on to create several more albums, as well as headlining his first national tour - The Lo Key Loves You Tour. In 2016 he released the album Jack Yo Beatz 3, featuring a music video for the song "Nasty", as well as collaborations with Redneck Souljers and The Jokerr.